2,6-dimethyl pyrazine, 108-50-9 - The Good Scents …
2,6-dimethyl pyrazine 2,6-dimethylpyrazine : ..
Yamada, K., Shimizu, A. & Ohta, A. (1993) Effects of dimethylpyrazine isomers on reproductive and accessory reproductive organs in male rats. .,16, 203–206.
2,6-Dimethylpyrazine For Synthesis | VWR
Yamada, K., Takahashi, H. & Ohta, A. (1992) Effects of 2,5-dimethylpyrazine on reproductive and accessory reproductive organs in female rats. ., 75, 99–107.
Recommendation for 2,5-dimethyl pyrazine …
5,6,7,8,-Tetrahydroquinoxaline (No. 952) was added to the diet of rats at a concentration calculated to result in an average daily intake of 19 mg/kg bw for males and females. Measurements of growth rate and food intake, haematological and clinical chemical parameters, liver and kidney weights, and gross and histopathological appearance revealed no significant difference between test and control animals (Oser, 1970).Groups of 10 male Charles River CD rats were housed five to a cage and given diets containing 5-methyl-6,7-dihydro-5-cyclopentapyrazine (No. 781) at a concentration of at 100, 1000, or 8200 mg/kg, equivalent to 5, 50, and 410 mg/kg bw per day, for 13 weeks. The animals had access to water and food. Appearance, behaviour, appetite, gross signs of toxic effects, and deaths were monitored daily and were similar among test and control animals. Weekly measure-ment of body weights and food consumption revealed a transient reduction in the food consumption of animals at the high dose during the first 3 weeks, which was attributed to poor palatability of the diet. The body-weight gain of animals at the high dose was lower than that of control animals, but the efficiency of food use was generally unaffected at any dose. Haematological examinations performed on 10 control rats and five rats from each test group immediately before termination at week 13 revealed normal values. At necropsy, the weights of the liver, kidneys, heart, lungs, testes, spleen, and thyroid and adrenal glands were recorded. Tissues from these organs and from the stomach, duodenum, ileum, caecum, and colon were subsequently preserved in formalin for histopathological examination. The absolute and relative weights of the kidney were increased in animals at the two higher doses, but these changes were not accompanied by any lesions, and no treatment-related lesions were found in other tissues. The NOEL was 50 mg/kg bw per day on the basis of significantly reduced body-weight gain at 410 mg/kg bw per day (Wheldon et al., 1967).: Groups of 16 male and 16 female Wistar rats were maintained on diets containing acetylpyrazine (No. 784), calculated to provide an average daily intake of 8.2 mg/kg bw. Control animals were given a basic diet. The study protocol was the same as that described above (Posternak et al., 1975). Measurements of growth rate, food intake, haematological and clinical chemical parameters, organ weights, and gross and histopathological appearance showed no differences between test and control animals (Posternak et al., 1975).