synthesis of a 1,4-di-t-buytl-2,5 ..

Groups of rats (male : female ratio unspecified) received diets containing 0.1% (20 rats) or 0.5% (40 rats) -dimethoxybenzene, (equivalent to dietary intakes of 50 mg/kg bw and 250 mg/kg bw, respectively (Food and Drug Administration, 1993)) for up to 2 years. Examination of appearance, behaviour, body weight and histolopathology yielded no significant differences between treated and control groups. Spontaneous diseases present in some of the animals were equally frequent among the test and control animals (Bär & Griepentrog, 1967).


Search results for 2,5-Di-t-butyl-1,4-benzohydroquinone at Sigma-Aldrich


-Dimethoxybenzene (No. 1250), administered at a dose of 700 mg/kg bw by gavage in rabbits, undergoes extensive -demethylation to -methoxyphenol (34%), followed by excretion as a glucuronic acid or sulfate conjugate. Trace amounts of hydroquinone were reported. -Demethylation of -dimethoxybenzene was also reported to occur in rabbit liver slices in vitro (Bray et al., 1955).

of DDB are 1,4-di-t-butyl-2,5 ..

In conclusion, the straight-chain aliphatic ethers, -butyl ethyl ether (No. 1231) and 1-ethoxy-3-methyl-2-butene (No. 1232) may undergo -dealkylation in vivo to yield the corresponding alcohol and aldehyde that subsequently undergo complete oxidation in the fatty acid pathway and tricarboxylic acid cycle. Alicyclic ethers principally undergo ring-hydroxylation by CYP450, conjugation with glucuronic acid and then excretion in the urine. The aromatic ethers may undergo ring-hydroxylation, -demethylation or side-chain oxidation, depending upon the position of the substituents, followed by conjugation with glucuronic acid, sulfate or glycine. The data demonstrate that the substances in this group are rapidly absorbed, distributed, metabolized and excreted.

Electroactive ionic liquids based on 2,5-ditert-butyl-1,4-dimethoxybenzene and triflimide ..
Answer to ir spectroscopy please assign peaks of 1,4 di-t-butyl-2,5-dimethoxybenzene

4 isomer 1,4-di- t-butyl-2,5- dimethoxybenzene the major ..

Assays for sex-linked recessive lethal mutations in were performed using 5 mmol/l of propylanisole (No. 1244), 25 mmol/l of -dimethoxybenzene (No. 1249), 10 mmol/l of dibenzyl ether (No. 1256), 25 mmol/l ofnaphthyl ethyl ether (No. 1258), or 25 mmol/l ofnaphthyl isobutyl ether (No. 1259) (Wild et al., 1983). None of these substances was reported to give positive results in this assay (Wild et al., 1983).

Synthesis of 1,4-Di-t-butyl-2,5-dimethoxybenzene byFriedel-Crafts Alkylation of 1 ..


Electrophilic aromatic substitution is one of the key reactions in organicchemistry. The Friedel-Crafts alkylation of 1,4-dimethoxybenzene withtert-butyl alcohol is a popular introductory organic laboratoryexperiment to illustrate the features of electrophilic aromatic substitution(Williamson et al., 2006). The product,1,4-di-tert-butyl-2,5-dimethoxybenzene, (I), has also been reported toexhibit a dramatic change of shape during crystal growth (Blatchly andHartshorne, 1966). Recently, a synthesis involving electrophilicaromaticsubstitution coupled with a Wagner-Meerwein rearrangement using1,4-dimethoxybenzene with 2-methyl-2-butanol was reported (Polito etal., 2010). However, the product,1,4-bis(1,1-dimethylpropyl)-2,5-dimethoxybenzene (II), has no dramatic crystalgrowth behaviour. To obtain the perspectives on both development ofsophisticated laboratory activity in organic chemistry and the relationshipbetween crystal growth and molecular structure, the X-ray diffraction analysisof the title compound (II) was performed, and the structural features of (I)and (II) discussed in this article. The crystal structure of (I) has alreadybeen reported (Rosokha and Kochi, 2007).

Synthesis of a polymeric 2,5-di-t-butyl-1,4-dialkoxybenzene and its evaluation as a ..

SDS Search - EH&S - WKU - Western Kentucky University

Onsite wastewater treatment systems, such as septic systems, serve 20% of U.S. households and are common in areas not served by wastewater treatment plants (WWTPs) globally. They can be sources of nutrients and pathogen pollution and have been linked to health effects in communities where they contaminate drinking water. However, few studies have evaluated their ability to remove organic wastewater compounds (OWCs) such as pharmaceuticals, hormones, and detergents. We synthesized results from 20 studies of 45 OWCs in conventional drainfield-based and alternative onsite wastewater treatment systems to characterize concentrations and removal. For comparison, we synthesized 31 studies of these same OWCs in activated sludge WWTPs. OWC concentrations and removal in drainfields varied widely and depended on wastewater sources and compound-specific removal processes, primarily sorption and biotransformation. Compared to drainfields, alternative systems had similar median and higher maximum concentrations, reflecting a wider range of system designs and redox conditions. OWC concentrations and removal in drainfields were generally similar to those in conventional WWTPs. Persistent OWCs in groundwater and surface water can indicate the overall extent of septic system impact, while the presence of well-removed OWCs, such as caffeine and acetaminophen, may indicate discharges of poorly treated wastewater from failing or outdated septic systems.