1,4-DI-TERT-BUTYL-2,5-DIMETHOXYBENZENE | 7323 …
-Dimethoxybenzene (No. 1250), administered at a dose of 700 mg/kg bw by gavage in rabbits, undergoes extensive -demethylation to -methoxyphenol (34%), followed by excretion as a glucuronic acid or sulfate conjugate. Trace amounts of hydroquinone were reported. -Demethylation of -dimethoxybenzene was also reported to occur in rabbit liver slices in vitro (Bray et al., 1955).
of DDB are 1,4-di-t-butyl-2,5 ..
In conclusion, the straight-chain aliphatic ethers, -butyl ethyl ether (No. 1231) and 1-ethoxy-3-methyl-2-butene (No. 1232) may undergo -dealkylation in vivo to yield the corresponding alcohol and aldehyde that subsequently undergo complete oxidation in the fatty acid pathway and tricarboxylic acid cycle. Alicyclic ethers principally undergo ring-hydroxylation by CYP450, conjugation with glucuronic acid and then excretion in the urine. The aromatic ethers may undergo ring-hydroxylation, -demethylation or side-chain oxidation, depending upon the position of the substituents, followed by conjugation with glucuronic acid, sulfate or glycine. The data demonstrate that the substances in this group are rapidly absorbed, distributed, metabolized and excreted.