KW - [1,2,4]Triazolo[3,4-b][1,3,4]oxadiazole
Curran, Ed., JAI Press, 1990, 147-219.
T1 - Synthesis, characterization, drug-likeness properties and determination of the in vitro antioxidant and cytotoxic activities of new 1,3,4-oxadiazole derivatives
(2017-08-07) - ISBN-13: 978-620-2-01481-6
AB - With an aim to introduce more biologically active compounds, S-substituted derivatives of 5-[1-(4-nitrophenylsulfonyl)piperidin-4-yl]-1,3,4-oxadiazole-2-thiol (3) were synthesized through four steps. In the first step, ethyl 1-(4-nitrophenylsulfonyl)piperidine-4-carboxylate (1)was synthesized by reacting 4-nitrobenzenesulfonyl chloride (a) and ethyl isonipacotate (b) in basic medium. In the second step, compound 1 and hydrazine monohydrate were converted to corresponding hydrazide (2). In third step, hydrazide (2), CS2 and KOH were refluxed in the presence of MeOH to acquire 5-(1-(4-nitrophenylsulfonyl)piperidin-4-yl)-1,3,4-oxadiazole-2-thiol (3). In the last step, alkyl/aralkylhalides (4a-o) and 3 were made to react in an aprotic polar solvent to get the final compounds, 2-(substitutedthio)-5-[1-(4-nitrophenylsulfonyl)piperidin-4-yl]-1,3,4-oxadiazole (5a-o). The synthesized compounds were structurally confirmed by spectroscopic techniques including 1H NMR, EIMS and IR. Finally the synthesized compounds were screened for antibacterial activity against five bacterial strains.
Soc. 2002, 124, 5288-5290; 2003, 125, 1877-1887.
A new class of pyrrolyl/pyrazolyl arylaminosulfonylmethyl 1,3,4-oxadiazoles, 1,3,4-thiadiazoles, and 1,2,4-triazoles were prepared and tested for antimicrobial activity. Amongst the tested compounds, 5c displayed high antimicrobial activity.
5392-40-5) in F344/N rats and B6C3F1 mice (feed studies).
Teaching and Research Experience: 1. AIMST University, Malaysia, Assoc. Professor (Jan 2009-till date).
2. Farooqia College of Pharmacy, India, Assistant Professor (July 2008-Dec 2008)
3. Bharathi College of Pharmacy, India, Lecturer (Jan 2007-July 2007)
4. Farooqia College of Pharmacy, India, Lecturer (Jan 2002-Jan 2007)
5. KMR College of Pharmacy, India, Lecturer (Jan 1989-Jun 1991)
Lee), Tetrahedron 2015, 71, 3741-3746.
A Click Chemistry Approach to Glycomimetics: Michael Addition of 2,3,4,6-tetra--acetyl-1-thio-β-D-glucopyranose to 4-deoxy-1,2--isopropylidene-L--pent-4-enopyranos-3-ulose - a Convenient Route to Novel 4-deoxy-(1->5)-5--thiodisaccharides.