Synthesis is a 1-step process — add acidic iso ..
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The synthesis of 6-acetyl-1,2,3,4-tetrahydropyridine, ..
The Evidence Investigator Phencyclidine Assay, tests for the parent molecule, 1-phenylcyclohexylpiperidine. Few substances cross-react with PCP in immunoassays 7.
Basic preparation of 1-phenylcyclohexylpiperidine ..
Abuse of amphetamines is a significant problem, although abuse of amphetamine is not widespread, methamphetamine abuse is and there has been much concern over 'ice', the solid form of methamphetamine (4). Amphetamine abusers can develop a tolerance for the drug, resulting in a psychological dependence and leading to drug abuse (3). Chronic abuse of amphetamine can lead to weight loss, hallucinations and paranoid psychosis, while acute overdose can cause agitation, hyperthermia, convulsions, coma and respiratory and/or cardiac failure (2). Large quantities of illegally synthesized amphetamines are manufactured. Many amphetamine analogues from the illicit market of the 1960s have been reintroduced and new analogues have been synthesized and marketed for their increased potency, altered pharmacological effects and difficulty of detection (1,4).
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Lycaeum > Leda > PCP Synthesis
EDC (acronym for 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride) is a water soluble carbodiimide which is typically employed in the 4.0-6.0 pH range. It is generally used as a carboxyl activating agent for the coupling of primary amines to yield amide bonds. Additionally, EDC can also be used to activate phosphate groups. Commons uses for this carbodiimide include peptide synthesis, protein crosslinking to nucleic acids and preparation of immunoconjugates.
PCP Synthesis Scanned from Recreational Drugs: ..
Di-tert-butyl dicarbonate is a reagent widely used in organic synthesis. This carbonate ester reacts with amines to give N-tert-butoxycarbonyl or so-called t-Boc derivatives. These derivatives do not behave as amines, which allow certain subsequent transformations to occur that would have otherwise affected the amine functional group. The t-Boc can later be removed from the amine using acids. Thus, t-Boc serves as a protective group, for instance in solid phase peptide synthesis. It is stable to most bases and nucleophiles, allowing for an orthogonal Fmoc protection.